FCSXpert.com is a resource developed by the FCSXpert™ Team at Sensor Technologies LLC for everyone interested in Fluorescence Correlation Spectroscopy (FCS). Our goal is to make the power of single-molecule detection with FCS accessible to all researchers. To that end, we have created a comprehensive and ever-expanding FCS Classroom and an easy-to-use FCS spectrometer.
Sensor Technologies was founded in 1988 by our CEO, John L. Hayes, and the late Dr. William Chick. Sensor Technologies specializes in fluorescence-based assay systems.
Sensor's QuantumXpert™ spectrometer provides the first easy-to-use and user friendly Fluorescence Correlation Spectroscopy platform. Fluorescence correlation spectroscopy is ideal for high sensitivity measurement of molecular diffusion and complexing. However, until now FCS has been prohibitively expensive and has required extensive technical expertise to use and understand. Sensor seeks to provide an easy-to-use, convenient, sensitive, versatile, and comprehensive solution to FCS-based assays.
Sensor's patented glucose sensing technology represents a fundamental advance in glucose monitoring. A tiny implant containing a fluorescent glucose-sensitive chemistry is placed beneath the surface of the skin in an outpatient procedure. The fluorescence signal from this implant is read across the skin to determine the patientís glucose concentration. Sensor's technology will allow long-term continuous glucose monitoring and, for the first time, raises the real possibility of closed-loop insulin delivery.
John L. Hayes, Chief Executive Officer at Sensor and BioHybrid Technologies, brings over thirty years of financial and operating experience in seed and early stage ventures to the management team. For ten years he was a founder, principal, and treasurer of Venture Founders, an early stage venture capital firm specializing in high technology ventures. His ten years in venture capital and twenty-one years as a founder of Sensor Technologies and BioHybrid Technologies provide expertise in operations management, strategic partnering, and commercialization to the management team.
He holds a Bachelor of Arts degree (1967) from Princeton University and a Masters of Business Administration (1969) from Harvard Business School. He held the position of Adjunct Professor at the International Institute for Management Development (IMD) from 1990 through 2002, where he was instrumental in organizing IMDís Entrepreneurship and Venture Capital curriculum.
David E. Wolf, Ph.D., Chief Scientific Officer and Vice President for Research and Development at Sensor and BioHybrid Technologies, is a biophysicist by training, having received his B.S. in Physics from Brooklyn College (1972) and his Ph.D. in Physics from Cornell University in 1979, where he participated in the early application of Fluorescence Correlation Spectroscopy and where he studied the action of immunoglobulins on cell surface receptors.
He was a National Cancer Institute Fellow at The Johns Hopkins University from 1978 - 1981. From 1981 - 1998 Dr. Wolf was on the faculty of the Worcester Foundation for Biomedical Research. From 1998 to 2002 he was Professor of Physiology at the University of Massachusetts Medical School. Dr. Wolf has a long history of private and federal funding of his research on peptide hormone signaling and cell activation.
He is respected for his expertise in biomedical engineering and bioinstrumentation and pioneered the use of FCS to study RNA diffusion inside of cell nuclei and the determination of membrane receptor stoichiometry. At Sensor Technologies he was awarded a grant from the National Institutes of Health to study the use of FCS in pathogen detection.
He directs the Analytical and Quantitative Light Microscopy program offered annually by The Marine Biological Laboratory at Woods Hole, Massachusetts. Dr. Wolf has authored and coauthored over fifty publications in respected scientific journals. He is coeditor of Digital Microscopy published by Elsevier Press, now in its third edition.
Dylan A. Bulseco, Ph.D., Director of Application Development at Sensor Technologies received his B.S. in Biology (1985) and Ph.D. in Biochemistry and Biophysics from Oregon State University in 1996. He was an American Psychological Association Minority Research Fellow as a doctoral student and appointed as a Neuroscience Training Grant Fellow at the Worcester Foundation for Biomedical Research, 1996-1998.
His research at the Worcester Foundation and University of Massachusetts Medical School, focused on development of fluorescence correlation spectroscopy instrumentation and novel data analysis algorithms. His research projects included characterization of signal transduction of G-protein coupled receptors as well as membrane tyrosine kinase receptors. He has continued work with single molecule detection technologies developing instrumentation as well as the sample preparation and assays required to effectively utilize these technologies. Dylan brings a broad range of technical expertise to Sensor Technologies including biochemistry, molecular biology, and biophysics; and a unique insight into data analysis and database solutions.
Shaohui (Jack) Huang, Ph.D., is a consultant and technical partner with Sensor Technologies. He contributes to the development and support of both of Sensor's technology platforms - Fluorescence Correlation Spectroscopy (FCS) and Continuous Glucose Monitoring Systems (CGMS). Jack is an optical microscopist carrying out interdisciplinary research in biophysics, biochemistry and cell biology. Sensor Technologies and Dr. Huang are working to launch sales, marketing and manufacturing of the QuantumXpertTM FCS system in China, where a team of local scientists will collaborate with Sensor Technologies to develop FCS assays. In addition, Dr. Huang is working to initiate clinical trials for Sensor's CGMS in China.
Dr. Huang started his undergraduate education at Zhongshan University in Guangzhou, China in 1988, and is currently an adjunct investigator at the Institute for Traumatic Medicine at the Medical School of Shanghai Jiao Tong University. Dr. Huang received his undergraduate (1993) and Ph.D. (1998) degrees in Biochemistry from the University of Kansas. His Ph.D. thesis investigated protein structure-function mechanism using time-resolved florescence spectroscopy. From 1999-2002, he was a postdoctor in Prof. Watt Webb's group at Cornell University, where he investigated protein-folding mechanism using FCS and cellular metabolism using multiphoton microscopy. From 2002-2009, he was a Research Assistant Professor at UMass Medical School, investigating glucose transporter trafficking in adipocytes using ultrafast/super-resolution deconvolution microscopy and total internal reflection fluorescence microscopy. Currently he is an investigator at the Institute for Environmental Medicine at UPenn School of Medicine where he studies molecular mechanisms governing surfactant homeostasis in the alveolar type II pneumocyte.